Acute Kidney Injury Severity And Its Impact On Clinical Outcomes In Critically Ill Patients.
DOI:
https://doi.org/10.65327/kidneys.v15i3.683Keywords:
Acute kidney injury, KDIGO, Critical illness, Mortality, DialysisAbstract
Acute kidney damage (AKI), which is linked to higher morbidity, mortality, and the need for organ support, is a frequent consequence in critically sick patients. This study evaluated AKI severity and its relationship with major clinical outcomes. A retrospective secondary-data-based observational study was conducted using data from 144 critically ill patients. Patients were classed as either AKI or non-AKI, and KDIGO Stages 1-3 were used to classify the severity of AKI. In-hospital mortality, mechanical ventilation, usage of vasoactive drugs, dialysis, ARDS, and length of hospital stay were among the clinical outcomes. Binary logistic regression, correlation analysis, independent t-test, chi-square test, frequency, and percentage were all used. AKI occurred in 41 patients (28.5%), with KDIGO Stage 3 being the most frequent severity category. Patients with AKI were older and had significantly higher APACHE II and IGS2/SAPS II scores. Mortality, mechanical ventilation, vasoactive drug use, dialysis requirement, and ARDS were significantly more frequent among AKI patients. Dialysis requirement increased significantly with advancing KDIGO stage. KDIGO severity correlated positively with AKI creatinine and negatively with urine output. AKI continued to be independently linked to in-hospital mortality in adjusted regression (adjusted OR=3.657, 95% CI: 1.225–10.915, p=0.020). Higher mortality, more organ support needs, and a more severe disease were all linked to AKI. Identification of critically sick individuals at increased risk of unfavorable outcomes may be aided by early detection and careful monitoring of renal impairment.
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