Modern Urological Approaches to Renal Stone Disease: Diagnostic Advances and Therapeutic Innovations

Abstract

Renal stone disease is a highly prevalent and recurrent urological condition with a growing global burden. Advances in imaging, endourological technology, and metabolic understanding have significantly transformed diagnostic and therapeutic strategies, necessitating an updated synthesis of contemporary management approaches. To review recent advances in the diagnosis and treatment of renal stone disease, with particular emphasis on imaging innovations, therapeutic technologies, and emerging trends toward personalised and value-based care. A narrative review of the literature was conducted, focusing on high-quality clinical trials, meta-analyses, guideline documents, and recent translational studies addressing diagnostic advances, medical and surgical therapies, and emerging technologies in renal stone disease. Modern diagnostic strategies emphasise low- and ultra-low-dose computed tomography, dual-energy imaging for stone characterisation, and the growing role of artificial intelligence in image interpretation and risk prediction. Therapeutic innovations include advancements in laser lithotripsy, miniaturised percutaneous nephrolithotomy, and refined ureteroscopic techniques, alongside optimised use of extracorporeal shock wave lithotripsy. Emerging non-invasive therapies, particularly burst wave lithotripsy, highlight a paradigm shift toward anaesthesia-free stone treatment. Personalised management incorporating metabolic evaluation, recurrence risk stratification, and preventive strategies has gained prominence, supported by predictive analytics and value-based care models. Contemporary management of renal stone disease reflects a transition toward precision medicine, minimally invasive therapy, and prevention-focused care. Ongoing research, equitable technology implementation, and high-quality clinical trials are essential to optimise outcomes and ensure sustainable, patient-centred stone management.