An Integrated Analysis Of Microbial Profiles, Drug Resistance And Socioeconomic Factors In Women With Diabetic Foot Ulcers

Abstract

Diabetic foot ulcers (DFUs) can lead to significant health issues, including amputations and mortality. The prevalence of diabetes is notably higher among middle-aged and elderly women, especially those in the 61-70 age group, with socioeconomic disparities significantly impacting access to care. This study highlights the severe complications of DFUs in patients with diabetes mellitus (DM), particularly among women from low-income groups, where limited access to healthcare, lack of awareness, and delayed medical interventions exacerbate the condition. The financial burden of managing chronic wounds, particularly in rural areas, further complicates the already substantial healthcare costs associated with diabetes care. The analysis involved screening 171 patients to identify bacterial pathogens and determine their antibiotic resistance patterns. The results indicated that Gram-positive bacteria, predominantly Staphylococcus aureus (72 %), and Gram-negative bacteria, including Klebsiella sp., and Pseudomonas sp., made up the remaining 28%. These infections are often polymicrobial, posing treatment challenges due to their resistance to commonly used antibiotics. Antibiotic susceptibility tests revealed varying degrees of resistance among the bacterial isolates. Particularly E. coli and Klebsiella sp. showed sensitivity to tested whereas Pseudomonas sp., and Acinetobacter sp. exhibited high levels of resistance. These findings emphasize the importance of precise diagnostic testing and the selection of appropriate antibiotic regimens to effectively manage these infections. Overall, this study underscores the critical need for targeted interventions addressing socioeconomic disparities and improving access to healthcare for at-risk populations. It also stresses the necessity for tailored antibiotic treatments to combat the complex bacterial infections associated with DFUs.