Comparative outcomes of calcineurin inhibitor-free versus standard immunosuppression in kidney transplant recipients
DOI:
https://doi.org/10.65327/kidneys.v14i4.562Keywords:
kidney transplantation; calcineurin inhibitors; CNI-free immunosuppression; belatacept; graft survival; nephrotoxicity; acute rejection; immunosuppressive strategiesAbstract
End-stage renal disease patients with improved lifestyle checks will profit more from a kidney
transplant than from any other type of treatment. Toxic sites with increased rejection risk are often treated
with calcineurin inhibitors (CNI) such as tacrolimus and cyclosporine-drugs. They are very effective at
reducing the risk of rejection but extremely nephrotoxic and metabolically disruptive protecting the body
from unwanted consequences while providing immunological assistance with CNI-free approaches, such
as belatacept-based and mTOR inhibitors that have been designed to mitigate the risk. To assess the effect
of CNI-based versus CNI-free immunosuppression, a big comparative study in more than one hundred
transplant patients was conducted on a one-year follow-up study. The belatacept-treated CNI-free cohort
was compared to the other cohort receiving the control treatment in addition to portal mycophenolate.
Objectives for the study were post-surgical organ rejection, survival of the transplanted organ, multiple
infections, and all nuances of nephrotoxic and metabolic derangement. The results were fewer fragments
and a CNI-free cohort, with improved acute rejection control and reduced total nephrotoxicity balance
pumps. These findings conclude that CNI-free is superior to CNI administered.
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Copyright (c) 2025 Chiranjeev Singh, Prachi Gurudiwan
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