A modern view on the prevention and metaphylaxis of urolithiasis

Authors

DOI:

https://doi.org/10.22141/2307-1257.14.2.2025.515

Keywords:

kidney stone disease (urolithiasis), prevention, metaphylaxis, recurrence, hypercalciuria, hyperoxaluria, uric acid stones, citrate, diet, hydration, intestinal microbiota, genetics, artificial intelligence, personalized medicine

Abstract

Urolithiasis (kidney stone disease) is a common multifactorial disorder of the urinary system with a high recurrence rate. This article presents current approaches to the prevention and metaphylaxis of urolithiasis. Primary prevention is based on lifestyle modification: adequate hydration, dietary recommendations, and reduced intake of sodium, animal protein, and oxalate-rich foods. Metaphylaxis is an individualized stra­tegy that considers stone composition, metabolic abnormalities, and comorbidities. The review also explores emerging areas of research, including the role of microbiota, genetic factors, information technologies, and artificial intelligence. Emphasis is placed on the need for a multidisciplinary approach and long-term patient follow-up to reduce the risk of recurrence and complications.

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References

Khalili P, Jamali Z, Sadeghi T, et al. Risk factors of kidney stone disease: a cross-sectional study in the southeast of Iran. BMC Urol. 2021 Oct 8;21(1):141. doi: 10.1186/s12894-021-00905-5.

Worcester EM, Coe FL. Clinical practice. Calcium kidney stones. N Engl J Med. 2010 Sep 2;363(10):954-963. doi: 10.1056/NEJMcp1001011.

Khan SR, Canales BK, Dominguez-Gutierrez PR. Randall's plaque and calcium oxalate stone formation: role for immunity and inflammation. Nat Rev Nephrol. 2021 Jun;17(6):417-433. doi: 10.1038/s41581-020-00392-1.

European Association of Urology (EAU). EAU Guidelines on Urolithiasis. Available from: https://uroweb.org/guidelines/urolithiasis.

Monga M, Murphy M, Paranjpe R, Cutone B, Eisner B. Prevalence of Stone Disease and Procedure Trends in the United States. Urology. 2023 Jun;176:63-68. doi: 10.1016/j.urology.2023.03.040.

Peerapen P, Thongboonkerd V. Kidney stone prevention. Adv Nutr. 2023 May;14(3):555-569. doi: 10.1016/j.advnut.2023.03.002.

Lee MR, Ke HL, Huang JC, Huang SP, Geng JH. Obesity-related indices and its association with kidney stone disease: a cross-sectional and longitudinal cohort study. Urolithiasis. 2022 Feb;50(1):55-63. doi: 10.1007/s00240-021-01288-w.

Ermer T, Nazzal L, Tio MC, Waikar S, Aronson PS, Knauf F. Oxalate homeostasis. Nat Rev Nephrol. 2023 Feb;19(2):123-138. doi: 10.1038/s41581-022-00643-3.

Recker P, Beck BB, Sikora P, et al. Chronic liver disease and hepatic calcium-oxalate deposition in patients with primary hyperoxaluria type I. Sci Rep. 2022 Oct 6;12(1):16725. doi: 10.1038/s41598-022-19584-9.

Crivelli JJ, Mitchell T, Knight J, et al. Contribution of Dietary Oxalate and Oxalate Precursors to Urinary Oxalate Excretion. Nutrients. 2020 Dec 28;13(1):62. doi: 10.3390/nu13010062.

Kamphuis GM, van Hattum JW, van Dongen-Lases EC, Henderickx MMEL, Beerlage HP. Introduction of a Standardized Approach of Electronic Urinary pH Monitoring to Assist Alkalization Therapy: A Uric Acid Urolithiasis Patient's Perspective. J Endourol. 2021 Oct;35(10):1563-1570. doi: 10.1089/end.2020.0621.

Yin S, Yang Z, Zhu P, et al. Association between added sugars and kidney stones in U.S. adults: data from National Health and Nutrition Examination Survey 2007-2018. Front Nutr. 2023 Aug 4;10:1226082. doi: 10.3389/fnut.2023.1226082.

Ong A, Brown G, Tokas T, Hameed BMZ, Philip J, Somani BK. Selection and Outcomes for Dissolution Therapy in Uric Acid Stones: A Systematic Review of Literature. Curr Urol Rep. 2023 Aug;24(8):355-363. doi: 10.1007/s11934-023-01164-7.

Peerapen P, Thongboonkerd V. Kidney stone proteomics: an update and perspectives. Expert Rev Proteomics. 2021 Jul;18(7):557-569. doi: 10.1080/14789450.2021.1962301.

Aziz W, Bashir A, Ather MH. Stone prevention: dietary factors, current evidence, and metabolic workup. In: Vickram AS, editor. Urolithiasis - Updates in Basic and Clinical Research. London, UK: IntechOpen; 2023. doi:10.5772/intechopen.111809.

Skubisz M, Torzewska A, Mielniczek-Brzóska E, Prywer J. Consumption of soft drinks rich in phosphoric acid versus struvite crystallization from artificial urine. Sci Rep. 2022;12:14332. doi: 10.1038/s41598-022-18357-8.

Zhang G, Deng T, Deng R, Sun X, He Y, Liu Z. Baseline urine pH is related to effective urine alkalization by short-term alkaline water supplementation: data from a self-controlled study in healthy Chinese volunteers following a systematic review and meta-analysis of literature. Transl Androl Urol. 2022 May;11(5):710-719. doi: 10.21037/tau-22-280.

Barghouthy Y, Somani BK. Role of Citrus Fruit Juices in Prevention of Kidney Stone Disease (KSD): A Narrative Review. Nutrients. 2021 Nov 17;13(11):4117. doi: 10.3390/nu13114117.

Ferraro PM, Taylor EN, Curhan GC. 24-Hour Urinary Chemistries and Kidney Stone Risk. Am J Kidney Dis. 2024 Aug;84(2):164-169. doi: 10.1053/j.ajkd.2024.02.010.

Chen YH, Lee JI, Shen JT, et al. The impact of secondhand smoke on the development of kidney stone disease is not inferior to that of smoking: a longitudinal cohort study. BMC Public Health. 2023 Jun 20;23(1):1189. doi: 10.1186/s12889-023-16116-6.

Ferre N, Parada E, Balaguer A, et al. Pharmacological interventions for preventing complications in patients with idiopathic hypercalciuria: A systematic review. Nefrologia (Engl Ed). 2021 Aug 12:S0211-6995(21)00150-8. doi: 10.1016/j.nefro.2021.04.007.

Abu-Ghanem Y, Kleinmann N, Erlich T, Winkler HZ, Zilberman DE. The impact of dietary modifications and medical management on 24-hour urinary metabolic profiles and the status of renal stone disease in recurrent stone formers. Isr Med Assoc J. 2021 Jan;23(1):12-16.

Khanam A, Singh G, Narwal S, Balram. Treatment and prevention of recurrent urolithiasis: insights on molecular mechanism of occurrence and medical care. Food Chem Adv. 2024;5:100751. doi: 10.1016/j.focha.2024.100751.

Pearle MS, Goldfarb DS, Assimos DG, et al.; American Urological Assocation. Medical management of kidney stones: AUA guideline. J Urol. 2014 Aug;192(2):316-324. doi: 10.1016/j.juro.2014.05.006.

Wang Q, Wang Y, Yang C, et al. Trends of Urolithiasis in China: A National Study Based on Hospitalized Patients from 2013 to 2018. Kidney Dis (Basel). 2022 Nov 7;9(1):49-57. doi: 10.1159/000527967.

Wang JS, Chiang HY, Chen HL, Flores M, Navas-Acien A, Kuo CC. Association of water intake and hydration status with risk of kidney stone formation based on NHANES 2009-2012 cycles. Public Health Nutr. 2022 Sep;25(9):2403-2414. doi: 10.1017/S1368980022001033.

Bhojani N, Bjazevic J, Wallace B, et al. UPDATE - Canadian Urological Association guideline: Evaluation and medical management of kidney stones. Can Urol Assoc J. 2022 Jun;16(6):175-188. doi: 10.5489/cuaj.7872.

Yuan T, Xia Y, Li B, et al. Gut microbiota in patients with kidney stones: a systematic review and meta-analysis. BMC Microbiol. 2023 May 19;23(1):143. doi: 10.1186/s12866-023-02891-0.

Geraghty R, Lovegrove C, Howles S, Sayer JA. Role of Genetic Testing in Kidney Stone Disease: A Narrative Review. Curr Urol Rep. 2024 Dec;25(12):311-323. doi: 10.1007/s11934-024-01225-5.

Theisen KM, Ayyash O, Pere M, et al. Defining 24-hour urine parameters and kidney stone risk of student athletes. Clin Nephrol. 2022 Feb;97(2):86-92. doi: 10.5414/CN110355.

Ungerer GN, Winoker JS, Healy KA, Shah O, Koo K. Mobile and eHealth technologies in the management and prevention of nephrolithiasis: A systematic review. Actas Urol Esp (Engl Ed). 2024 Jan-Feb;48(1):25-41. doi: 10.1016/j.acuroe.2023.06.010.

Altunhan A, Soyturk S, Guldibi F, et al. Artificial intelligence in urolithiasis: a systematic review of utilization and effectiveness. World J Urol. 2024 Oct 17;42(1):579. doi: 10.1007/s00345-024-05268-8.

Abid R, Hussein AA, Guru KA. Artificial Intelligence in Urology: Current Status and Future Perspectives. Urol Clin North Am. 2024 Feb;51(1):117-130. doi: 10.1016/j.ucl.2023.06.005.

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Published

2025-05-27

How to Cite

Krasiuk, I., Hrydniev, A., & Pylypenko, Y. (2025). A modern view on the prevention and metaphylaxis of urolithiasis. KIDNEYS, 14(2), 161–167. https://doi.org/10.22141/2307-1257.14.2.2025.515

Issue

Vol. 14 No. 2 (2025)

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Reviews

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