Assessment of the risk of rapid progression of chronic kidney disease

Abstract

Background. All over the world, chronic kidney di­sease (CKD) is a global problem. Prevention of CKD development, as well as the rapid progression of CKD, are the priority tasks of modern nephrology. A decrease in estimated glomerular filtration rate (eGFR) of more than 5 ml/min/1.73 m2/year is considered rapid progression of CKD. The purpose of the study was to assess the risk of rapid progression of CKD in patients with stage 1–3 CKD by determining urinary albumin (uAlb)/urinary uromodulin (uUmod) ratio and comparing the obtained results with eGFR and the Charlson Comorbidity Index (CCI) in these patients. ­Materials and methods. Patients were divided into 3 groups: group 1 (n = 46) — individuals with stage 1–3 CKD who had a CCI ≤ 2, group 2 (n = 45) — patients with stage 1–3 CKD who had CCI ≥ 3, and group 3 (n = 32) — people without CKD risk factors and wi­thout symptoms of kidney damage. Results. The results of the study showed that the linear regression between uAlb/uUmod and eGFR in groups 1 and 2 is statistically significant (p < 0.05). In the first group, the correlation coefficient (R) between uAlb/uUmod and eGFR is –0.295. In the second group, the correlation coefficient between uAlb/uUmod and eGFR is –0.32 — there is an average inverse relationship. ­Conclusions. If the ratio of uAlb/uUmod is more than 0.94, there is a risk of rapid progression of CKD. There is a need for further research in this direction to increase the effectiveness of predicting the rapid progression of CKD.