Рецидивирующие инфекции мочевой системы: доказательная база и дискутабельные вопросы мероприятий неантибактериальной профилактики

S.O. Vozianov; D.D. Ivanov; S.V. Kushnirenko; O.O. Shevchuk; V.O. Mazurets; O.V. Kushnirenko

doi:10.22141/2307-1257.9.4.2020.218238

Authors

S.O. Vozianov State Institution “Institute of Urology of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
D.D. Ivanov Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine http://orcid.org/0000-0003-2609-0051
S.V. Kushnirenko Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine http://orcid.org/0000-0001-5518-7210
O.O. Shevchuk State Institution “Institute of Urology of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
V.O. Mazurets State Institution “Institute of Urology of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
O.V. Kushnirenko State Institution “Institute of Urology of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine

DOI:

https://doi.org/10.22141/2307-1257.9.4.2020.218238

Keywords:

recurrent urinary tract infections, women, forinal

Abstract

Recurrent urinary tract infection (UTI) is a highly prevalent, costly, and burdensome condition affecting women of all ages, races, and ethnicities without regard for socioeconomic status, or educational level. Modern strategies aimed at preventing recurrent UTI are still not optimal, as evidenced by the relatively high prevalence of this nosology in women. The purpose of this article was to highlight and discuss both the evidence base and a number of unresolved issues in the management of recurrent UTI. The following topics of clinical interest are considered: diagnosis, age-related associations, continuous and intermittent antimicrobial prophylaxis, the effectiveness of modern non-antimicrobial prophylaxis, the potential role of forinal (a complex of D-mannose and cranberry fruit extract) in the prevention of recurrent UTI.

Downloads

Download data is not yet available.

References

Anger J, Lee U, Ackerman AL, Chou R, et al. Recurrent Uncomplicated Urinary Tract Infections in Women: AUA/CUA/SUFU Guideline. J Urol. 2019 Aug;202(2):282-289. doi:10.1097/JU.0000000000000296.

Bonkat G, Bartoletti R, Bruyere F, et al. Urological Infections: EAU Guidelines 2020. Available from: https://uroweb.org/guideline/urological-infections/.

National Institute for Health and Care Excellence (NICE). Urinary tract infection (recurrent): antimicrobial prescribing: NICE guideline [NG112]. Available from: https://www.nice.org.uk/guidance/ng112. Accessed: October 31, 2018.

Wiles K, Chappell L, Clark K, et al. Clinical practice guideline on pregnancy and renal disease. BMC Nephrol. 2019 Oct 31;20(1):401. doi:10.1186/s12882-019-1560-2.

Perepanova TS, Kozlov RS, Rudnov VA, Siniakova LA, Palagin IS. Antimikrobnaia terapiia i profilaktika infektsii pochek, mochevyvodiashchikh putei i muzhskikh polovykh organov: Federal'nye klinicheskie rekomendatsii [Antimicrobial therapy and prevention of infections of the kidneys, urinary tract and male genital organs]. Moscow; 2020. 63 р. (in Russian).

Torshin IYu, Apolikhina IА, Gromov AN, Gromova OA. Concerning the properties of D-mannose: anti-inflammatory and antitumor effects. Experimental and clinical urology. 2020;(2):164-170. doi:10.29188/2222-8543-2020-12-2-164-170. (in Russian).

Porru D, Parmigiani A, Tinelli C, et al. Oral D-mannose in recurrent urinary tract infections in women: a pilot study. J Clin Urol. 2014;7(3):208-213. doi:10.1177/2051415813518332.

Gan J, Dou Y, Li Y, et al. Producing anti-inflammatory macrophages by nanoparticle-triggered clustering of mannose receptors. Biomaterials. 2018 Sep;178:95-108. doi:10.1016/j.biomaterials.2018.06.015.

Gonzalez PS, O'Prey J, Cardaci S, et al. Mannose impairs tumour growth and enhances chemotherapy. Nature. 2018 Nov;563(7733):719-723. doi:10.1038/s41586-018-0729-3.

González de Llano D, Moreno-Arribas MV, Bartolomé B. Cranberry Polyphenols and Prevention against Urinary Tract Infections: Relevant Considerations. Molecules. 2020 Aug 1;25(15):3523. doi:10.3390/molecules25153523.