Cardiovascular pathologies in the urban population of the Republic of Uzbekistan with chronic kidney disease on hemodialysis

Abstract

Background. Chronic kidney disease (CKD) is now an undeniable global public priority. Although the prevalence and health effects of CKD have been studied primarily in economically developed countries, the burden of the disease is even greater in developing countries. For this purpose, we decided to study the structure of cardiovascular pathologies in patients with stage 5 chronic kidney disease receiving programmed hemodialysis of the urban population. Materials and methods. In the course of the scientific study, 104 patients permanently residing in the city of Tashkent were examined. The average age of the patients was 49.7 ± 11.7 years. The study included patients with a clinically established diagnosis of stage 5 CKD due to nephropathies of various origins. Glomerular filtration rate was calculated based on serum creatinine concentration using the CKD-Epi formula. Hemodialysis sessions were carried out according to the scheme 4 hours 3 times a week. Results. According to the results of a study of 104 patients, 62 (59.6 %) of the examined had cardiovascular pathology. The most frequent occurrence was arterial hypertension, almost 53 % (n = 55) of patients suffered from it. Stable angina was detected in 38.5 % patients (n = 40). Chronic heart failure was found in more than 19 % (n = 20) of patients. Conclusions. The results of the analysis of 104 CKD patients on hemodialysis demonstrated that the main pathologies of the cardiovascular system in urban patients were chronic heart failure, arterial hypertension, angina, and various arrhythmias. It can be assumed that the comorbid pathology of the cardiovascular system dominates in the structure of cardiovascular lesions in patients with end-stage chronic kidney disease receiving programmed hemodialysis and is not sex-related. It also may be noted the high incidence of diabetes mellitus in the examined patients with cardiovascular disease, which corresponds to the literature data.