Renal Involvement at Cryoglobulinemic Vasculitis

Abstract

The aim of the work was to evaluate the frequency and nature of renal lesion in patients with cryoglobulinemic vasculitis. According to clinical, laboratory and sonographic data renal damage is observed in 2/3 of the number of patients that is associated with the presence of the pathology of myocardium, joints, lungs and peripheral nervous system, with the severity of integrated extrarenal signs of the disease, and kidney failure is diagnosed in every second observation, nephrotic syndrome — in every sixth one. Morphological lesion of glomeruli, tubules and stroma of the kidneys resembles primary mesangioproliferative or mesangiocapillary glomerulonephritis with severe tubulointerstitial component. Renal function and the rate of progression of nephropathy influence the levels of high molecular weight proteins in the urine (fibronectin, b2-microglobulin) and nitrogen products (uric acid, nitrites), as well as physical and chemical surface features of urine.