Disorders of Lipid Metabolism and its Correction in Chronic Kidney Disease

Authors

  • O.O. Melnyk «Optima Pharm», Kyiv

DOI:

https://doi.org/10.22141/2307-1257.2.16.2016.72751

Keywords:

chronic kidney disease, cholesterol, triglycerides, low density lipoproteins, high density lipoproteins, apo AI, apo AII, lipoprotein lipase, hepatic triglyceride lipase, statins, fibrates, nicotinic acid

Abstract

Chronic kidney disease — a proven risk factor of the development and progression of lipid metabolism disorders. The basis of these disorders — an increase in blood plasma cholesterol, triglycerides, low density lipoproteins and decreased levels of high density lipoproteins, apo AI and apo AII. There has been a decrease in the activity of enzymes: lipoprotein lipase, hepatic triglyceride lipase, lecithin-cholesterol acyltransferase. The use of lipid-modifying drugs — statins, fibrates, nicotinic acid was proposed.

Downloads

Download data is not yet available.

Author Biography

O.O. Melnyk, «Optima Pharm», Kyiv

Project Manager of the Specialized Medical Center

References

El Nahas A.M., Bello A.K. Chronic kidney disease: The global challenge // Lancet. — 2005. — № 365. — Р. 331-40.

Levey A.S., Atkins R., Coresh J. et al. Chronic kidney disease as a global public health problem: Approaches and initiatives — A position statement from Kidney Disease Improving Global Outcomes // Kidney Int. — 2007. — № 72. — Р. 247-59.

Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 Clinical Proctice Guideline for the Evaluation and Management of Chronic Kidney Disease // Kidney Int. — 2013. — 3(Suppl.). — Р. 1-150.

Gröne E.F., Gröne H.J. Does hyperli pidemia injure the kidney? Nature clinical practice // Nephrology. — 2008. — № 4(8). — Р. 424-5.

Sarnak M.J., Levey A. Cardiovascular disease and chronic renal disease: a new paradigm // Am. J. Kidney Dis. — 2000. — № 35(4). — S117-131.

Keane W.F. Lipids and the kidney // Kidney international. — 1994. — № 46(3). — Р. 910-20.

Tareeva I.E., Kutyrina M.I., Nikolaev A.Yu. The braking of chronic renal failure // Therapeutic Archives. — 2000. — № 6. — Р. 9-14.

Virchow R., Chance F. Cellular pathology, as based on physiological and pathological histology // J. Churchill. — London, 1860. A more precise account of fatty metamorphosis. — Р. 351.

Jay V. Richard Bright: physician extraordinaire // Arch. Pathol. Lab. Med. — 2000. — № 124. — Р. 1262-1263.

Moorhead J.F., Chan M.K., El-Nahas M., Varghese Z. Lipid nephrotoxicity in chronic progressive glomerular and tubulo-interstitial disease // Lancet. — 1982. — № 2. — Р. 1309-11.

Grone H.J., Walli A., Grone E., Niedmann P., Thiery J., Seidel D., Helmchen U. Induction of glomerulosclerosis by dietary lipids. A functional and morphologic study in the rat // Lab. Invest. — 1989. — № 60. — Р. 433-46.

Vaziri N.D., Norris K. Lipid disorders and their relevance to outcomes in chronic kidney disease // Blood Purif. — 2011. — № 31(1–3). — Р. 189-96.

Chen S.C., Hung C.C., Kuo M.C. et al. Association of dyslipidemia with renal outcomes in chronic kidney disease // PLoS One. — 2013. — № 8(2). — Е55643.

Urazlina C.E., Zhdanova T.V., Nazarov A.V. et al. Lipid metabolism in patients with chronic renal failure // Ural Medical Journal. — 2011. — № 2(80). — Р. 122-6.

Rovin B.H., Tan L.C. LDL stimulates mesangial fibronectin production and chemoattractant expression // Kidney international. — 1993. — № 43. — Р. 218-25.

Keane W.F., O’Donnell M.P., Kasiske B.L. Oxidative modification of low-density lipoproteins by mesangial cells // Journal of the American Society of Nephrology. — 1993. — № 4. — Р. 187-94.

Kume S., Uzu T., Araki S. et al. Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat diet // Journal of the American Society of Nephrology. — 2007. — № 18. — Р. 2715-23.

Colina I.B. Hyperli pidemia in patients with chronic kidney disease: features and approaches to treatment // The attending physician. — 2012. — № 1. — Р. 63-70.

Colina I.B., Stavrovskaya U., Shilov E.M. Dysli pidemia, and chronic progressive renal disease // Ter. archive. — 2004. — № 76(9). — Р. 75-8.

Abrass C.K. Cellular lipid metabolism and the role of lipids in progressive renal disease // Am. J. Nephrol. — 2004. — № 24. — Р. 46-53.

Vaziri N.D. Dyslipidemia of chronic renal failure: the nature, mechanisms, and potential consequences // Am. J. Physiol. Renal. Physiol. — 2006. — № 290. — F262-F272.

Bhowmik D., Tiwari S.C. Metabolic syndrome and chronic kidney disease // Indian J. Nephrol. — 2008. — № 18(1). — Р. 1-4.

Trevisan R., Dodesini A.R., Lepore G. Lipids and renal disease // J. Am. Soc. Nephrol. — 2006. — № 17. — S145-S147.

Kuznetsova E.B., Zhdanov T.V., Sadykova Yu.R. et al. Metabolic syndrome in nephrology patients // Ural Medical Journal. — 2011. — № 4. — Р. 34-41.

KDIGO Clinical Practice Guideline for Lipid Management in Chronic Kidney Disease // Kidney International. — 2013. — 3(Suppl.). — Р. 268-70.

National Kidney Foundation. KDOQI Clinical Practice Guidline for Diabetes and CKD: 2012 update // Am. J. Kidney Dis. — 2012. — № 60(5). — Р. 850-886.

Kidney Disease: Improving Global Outcomes (KDIGO) Lipid Work Group. KDIGO Clinical Practice Guidline for Lipid Management in Chronic Kidney Disease // Kidney Int. — 2013. — 3(Suppl.). — Р. 259-305.

Published

2021-09-10

How to Cite

Melnyk, O. (2021). Disorders of Lipid Metabolism and its Correction in Chronic Kidney Disease. KIDNEYS, (2.16), 85–95. https://doi.org/10.22141/2307-1257.2.16.2016.72751

Issue

Section

Lecture